Best Supplements for PCOS: Natural Support Backed by Science

If you’ve been diagnosed with Polycystic Ovarian Syndrome (PCOS), you’ve likely heard a lot of conflicting advice. PCOS is complex, and its symptoms can be frustrating: weight gain, irregular periods, acne, excess hair, fatigue, and fertility issues. But alongside medical treatment, the right supplements can make a meaningful difference.

At HOOT HRT, we believe in combining evidence-based hormone therapy with targeted supplements to help support your metabolism, hormone balance, and long-term wellness.

Here are the top science-backed supplements we recommend for PCOS:

1. Myo-Inositol + D-Chiro-Inositol

Helps restore ovulation, improve insulin sensitivity, lower testosterone, and support fertility. This combination mimics natural insulin and ovarian signaling and is often a first-line supplement.

2. N-Acetylcysteine (NAC)

A powerful antioxidant that improves insulin sensitivity, lowers testosterone, and reduces inflammation. NAC also supports ovulation and egg quality.

3. Chromium Picolinate

A trace mineral that enhances glucose metabolism and reduces insulin resistance. Great for blood sugar regulation and reducing carb cravings.

4. Omega-3 Fatty Acids

Supports hormone production, reduces inflammation, and may help lower androgens. Also supports mental health and cardiovascular health.

5. Vitamin D3

Women with PCOS are often deficient. Vitamin D supports mood, immune health, insulin sensitivity, and menstrual cycle regulation.

6. Berberine

Known as a natural alternative to metformin, berberine helps improve insulin resistance, reduce testosterone, and aid in weight loss.

7. Magnesium

Often depleted in PCOS. Helps regulate blood sugar, reduce stress, improve sleep, and support hormone balance.

Bonus Support:

• Zinc: May help reduce androgens and support skin/hair health.

• Probiotics: Supports gut health, which is essential for hormone detoxification.

• B-Complex Vitamins: Important for energy, mood regulation, and hormone metabolism.

Why Supplements Matter

Supplements don’t replace medication, but when used intentionally, they can support your body's ability to regulate insulin, reduce inflammation, balance hormones, and improve your quality of life.

At HOOT HRT, we take a full-spectrum approach to PCOS. After we run labs and assess your symptoms, we often integrate nutraceuticals into your customized care plan—especially for patients who are metformin-intolerant or seeking more natural support.

We don’t guess. We test. And we create real solutions that work.

Visit www.hoothrt.com to schedule your initial consultation and let’s get your hormones working for you, not against you.